Applications
Alfacalcidol is a vitamin D supplement used to treat deficiency in conditions including hypocalcemia (low blood calcium levels), rickets (bone weakness), and others. Ergocalciferol is a class of medication called vitamin D analogs. This works by helping the body to use more calcium in foods or supplements.
 
Description
Alfacalcidol is a vitamin D analogue used for the management of hypocalcemia, secondary hyperparathyroidism, and osteodystrophy in patients with chronic renal failure, as well as some types of rickets and osteomalacia.
 
Preparation
The preparation method comprises the steps as follows: taking vitamin D3 as a raw material; removing most of trans-isomer impurities generated after chemical reaction by utilizing Diels-Alder reaction; and refining and purifying by preparative high pressure liquid chromatography to prepare high-purity alfacalcidol.
 
Chemical Properties
Alfacalcidol is a white to almost white crystalline powder with low solubility in water, recognized for its role as a prohormone of calcitriol, an active form of vitamin D, essential for calcium and phosphate metabolism.
 
Definition
Alfacalcidol is a synthetic form of vitamin D used to treat disorders related to calcium and phosphate metabolism, aiding in the absorption of calcium from the gastrointestinal tract.