Applications
Adefovir dipivoxil is a nucleoside analogue used for chronic hepatitis B infection, including against lamivudine-resistant strains. It is administered as the oral prodrug (plasma t½ 8 h, intracellular t½ of active metabolite 17 h).
 
Description
Adefovir dipivoxil, previously called bis-POM PMEA, with trade names Preveon and Hepsera, is an orally-administered acyclic nucleotide analog reverse transcriptase inhibitor (ntRTI) used for treatment of hepatitis B. It is ineffective against HIV-1. Adefovir dipivoxil is the diester prodrug of adefovir.
 
Preparation
The synthesis of adefovir dipivoxil is completed by addition of the chloromethyl pivalate to a solution of the corresponding phosphonic acid in N-methylpyrrolidone (NMP), using triethylamine as base. Figure 2. Synthetic scheme of crystalline adefovir dipivoxil.
 
Chemical Properties
Adefovir dipivoxil API is a white to off-white crystalline powder with low solubility in water, recognized for its antiviral properties in treating chronic hepatitis B by inhibiting viral DNA polymerase.
 
Definition
Adefovir dipivoxil API is an organic compound used in the treatment of chronic hepatitis B, functioning as a nucleotide analogue inhibiting viral DNA replication.