Applications
1H-Benzimidazole-5-carboxylic acid is utilized as a key intermediate in the synthesis of pharmaceuticals, including antifungal and antiviral agents, due to its benzimidazole scaffold with potential biological activities.
 
Description
1H-Benzimidazole-5-carboxylic acid is an organic compound with a benzimidazole ring and a carboxylic acid group, pivotal in pharmaceutical synthesis due to its versatile reactivity and potential pharmacological properties.
 
Preparation
Synthesis of 1-(4-methoxyphenethyl)-1H-benzimidazole-5-carboxylic acid derivatives was outlined in Scheme 1. 4-Fluoro-3-nitro-benzoic acid 1 was dissolved in dichloromethane (MDC). Methanol and thionyl chloride was added to it, and under reflux condition the compound 2 was formed.
 
Chemical Properties
1H-Benzimidazole-5-carboxylic acid is a crystalline solid with a characteristic benzimidazole structure, exhibiting stability and potential reactivity in various chemical reactions.
 
Definition
1H-Benzimidazole-5-carboxylic acid is an organic compound featuring a benzimidazole ring with a carboxylic acid group at the 5-position, significant in pharmaceutical synthesis and pharmacological research.
Chemical formula    C8H6N2O2.
Molar mass             162.15 g/mol
Density            0.85 g/cm3
Boiling point      288.82°C     
Technical Analysis
Specification        Typical Values
Colour (APHA)          white
CAS NO.              15788-16-6
Density           1.3264
Solubility            DMSO (Slightly), Methanol (Slightly, Heated)
1H-Benzimidazole-5-carboxylic acid is an organic compound with a carboxylic acid group and a benzimidazole ring.