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Applications
Abacavir is an antiviral nucleoside reverse transcriptase inhibitor used in combination with other antiretrovirals for the treatment of HIV. Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS.
Description
Abacavir (ABC) is a powerful nucleoside analog reverse transcriptase inhibitor (NRTI) used to treat HIV and AIDS. Chemically, it is a synthetic carbocyclic nucleoside and is the enantiomer with 1S, 4R absolute configuration on the cyclopentene ring.
Preparation
Stage-1 : N-(2-Amino-4,6-dichloro-5-pyrimidinyl)formamide is reacted with (1S,4R)- 4-Amino-2-cyclopentene-1- methanol Tartrate, Sodium Carbonate in presence of Isopropyl Alcohol solvent media to get Stage-1 Compound.
Chemical Properties
Abacavir sulfate is a white crystalline powder with high solubility in water, known for its antiviral properties, targeting HIV reverse transcriptase, and often used in pharmaceutical formulations.
Definition
Abacavir sulfate is a pharmaceutical compound used in the treatment of HIV/AIDS, inhibiting the reverse transcriptase enzyme critical for viral replication.
Abacavir Sulfate
Country of Origin Made in India Usage Pharma Formula C14H20N6O5S Molecular Weight 384.41 g/mol Storage Temperature 2-8degC Physical Appearance A solid Storage Store at -20°C M.Wt 384.41 Cas No. 188062-50-2 Solubility insoluble in EtOH; ≥12.3 mg/mL in H2O; ≥8.63 mg/mL in DMSO with ultrasonic Chemical Name [(1S,4R)-4-[2-amino-6-(cyclopropylamino)purin-9-yl]cyclopent-2-en-1-yl]methanol;sulfuric acid Packaging Size As Per Requirement
