Applications
5-Amino-2-methylbenzenesulfonamide is an intermediate for the synthesis of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
 
Description
5-Amino-2-methylbenzenesulfonamide is an intermediate for the synthesis of Pazopanib (P210925), an oral angiogenesis inhibitor targeting VEGFR and PDGFR.
 
Preparation
The invention relates to a preparation method of 2-methyl-5-aminobenzenesulfonamide, which comprises the following steps: s1 sulfonation: dissolving paranitrotoluene and chlorosulfonic acid in an organic solvent I, stirring for reaction, and performing post-treatment to obtain 2-methyl-5-nitrobenzenesulfonyl chloride; s2 hydrogenation addition reaction: adding the 2-methyl-5-nitrobenzenesulfonyl chloride in the step S1 into a hydrogenation kettle, sequentially adding a catalyst, ammonia water and an organic solvent II, reacting at high temperature and high pressure, and treating after reaction to obtain light yellow solid 2-methyl-5-aminobenzenesulfonamide. The method has the advantages of short route, high product purity and easy industrial production.
 
Chemical Properties
Appearance White to Light yellow to Light orange powder to crystal
Purity(HPLC) min. 98.0 area% Purity(Nonaqueous Titration) min. 98.0 %
Melting point 165.0 to 170.0 °C
 
 
 
 
Sihauli Chemicals is one of the leading 5-amino-2- Methyl Benzene Sulfonamide  Manufacturer and Exporter form India. Sihauli Chemicals Supply 5-amino-2- Methyl Benzene Sulfonamide to Asia, Africa, Europe, North & South America and Oceania.
Our Global Presense:
Asia: Bangladesh, Burma (Myanmar), China, Hong Kong (UK), Indonesia, Iran, Israel, Japan, Jordan, Kampuchea (Cambodia), Kuwait, Laos, Lebanon, Macao (Portuguese), Malaysia, Maldives, Mongolia, Nepal, Oman, Philippines, Qatar, Saudi Arabia, Singapore, South Korea, Sri Lanka, Taiwan, Thailand, Turkey, United Arab Emirates, Vietnam.
Europe: Albania, Andorra, Austria, Belgium, Bulgaria, Cyprus, Czechoslovakia, Denmark, Finland, France, German Democratic Republic, Gibraltar, Greece, Hungary, Iceland, Ireland, Italy, Liechtenstein, Luxembourg, Malta, Monaco, Netherlands, Norway, Poland, Portugal, Romania, San Marino, Spain, Sweden, Switzerland, United Kingdom, U.S.S.R., Yugoslavia. Africa: Algeria, Angola, Egypt, Ethiopia, Gabon, Ghana, Kenya, Liberia, Libya, Madagascar, Mauritius, Morocco, Mozambique, Namibia, Nigeria, Reunion (France), Seychelles, Somalia, South Africa, Sudan, Tanzania, Tunisia, Uganda, Zambia, Zimbabwe.
North America: Bahamas, Barbados, Bermuda, British Virgin Islands, Canada, Costa Rica, Cuba, Dominica, El Salvador, Greenland (Denmark), Grenada, Guatemala, Haiti, Honduras, Jamaica, Martinique, Mexico, Montserrat, Nicaragua, Panama, Puerto Rico (USA), St. Vincent & the Grenadines, Trinidad & Tobago, USA, Virgin Islands.
South America: Argentina, Bolivia, Brazil, Chile, Colombia, Ecuador, French Guiana, Guyana, Paraguay, Peru, Venezuela.
Oceania: Australia, New Zealand, Solomon Islands, Wallis & Futuna Islands (France).