Palmitoyl Tripeptide-38   is a synthetic lipopeptide composed of a tripeptide linked to palmitic acid, designed to enhance skin penetration and stability. It is widely known in the cosmetic industry as a key component of advanced anti-aging formulations (often associated with Matrixyl® synthe’6).
This peptide works by stimulating the synthesis of multiple essential components of the skin’s extracellular matrix, including collagen types I, III, and IV, as well as hyaluronic acid and fibronectin. By targeting several layers of the skin structure, it helps rebuild and reinforce the skin from within.
As a result, Palmitoyl Tripeptide-38 helps reduce the appearance of wrinkles—especially deep lines such as forehead wrinkles and crow’s feet—while improving skin firmness, smoothness, and hydration. It also enhances overall skin texture and promotes a more youthful, plump appearance.
 
 
Applications: Used in advanced anti-aging skincare products such as serums, creams, lotions, and eye treatments to reduce wrinkles, improve skin firmness, boost collagen, and enhance overall skin texture.
Appearance:  White to off-white powder (often supplied as a clear to slightly opalescent solution)
Solubility:  Water-dispersible; soluble in water-based formulations and emulsions
pH Range: Typically stable in formulations with pH 4.0 – 7.0
Chemical Formula: C₃₃H₆₅N₉O₇
Cas. No: 1447824-23-8